0) HR (bpm) 58.3 ± 4.9 66.3 ± 6.7 62.3 ± 6.9 0.103 58.0 (54.0 – 63.0) 64 (61.0 – 76.0) 62.5 (54.0 – 76.0) QTcB (msec) 383.5 ± 7.6 376.8 ± 15.6 380.1 ± 11.9 0.470   383.7 (374.0 – 392.5) 374.4 (360.3 – 398.0) 379.3 (360.3 – 398.0)   Data are mean ± SD (top row); this website median and (range) provided in bottom row. Table 2 Metabolic panel and blood counts of 8 healthy men assigned to MSM Variable

1.5 g/day (n = 4) 3.0 selleck inhibitor g/day (n = 4) All Subjects p-value Glucose (mg·dL-1) 85.3 ± 2.6 96.3 ± 7.1 90.8 ± 7.7 0.028 85.0 (83.0 – 88.0) 94.5 (90.0 – 106.0) 89.0 (83.0 – 106.0) BUN (mg·dL-1) 15.8 ± 4.8 12.8 ± 2.6 14.3 ± 3.9 0.314 16.0 (10.0 – 21.0) 13.5 (9.0 – 15.0) 14.0 (9.0 – 21.0) Creatinine (mg·dL-1) 1.0 ± 0.1 0.9 ± 0.1 1.0 ± 0.1 0.561 1.0 (0.8 – 1.0)

0.9 (0.8 – 1.0) 1.0 (0.8 – 1.0) AP (Units·L-1) 73.5 ± 25.0 85.0 ± 23.4 79.3 ± 23.2 0.527 71.0 (47.0 – 105.0) 78.0 (66.0 – 118.0) 75.5 (47.0 – 118.0) AST (Units·L-1) 19.8 ± 4.9 16.0 ± 2.4 17.9 ± 4.1 0.222 19.5 (14.0 – 26.0) 16.5 (13.0 – 18.0) 18.0 (13.0 – 26.0) OSI-906 cost ALT (Units·L-1) 21.3 ± 10.9 20.0 ± 6.7 20.6 ± 8.4 0.851 17.0 (14.0 – 37.0) 21.0 (11.0 – 27.0) 20.0 (11.0 – 37.0) WBC (thousand·μL-1) 5.60 ± 1.49 7.10 ± 1.79 6.35 ± 1.72 0.245 5.9 (3.6 – 7.1) 7.1 (5.0 – 9.3) 6.4 (3.6 – 9.3) RBC (million·μL-1) 5.2 ± 0.3 5.4 ± 0.2 5.3 ± 0.3 0.255 5.1 (4.9 – 5.7) 5.5 (5.2 – 5.6) 5.3 (4.9 – 5.7) Hemoglobin (g·dL-1) 14.9 ± 0.4 15.7 ± 0.9 15.3 ± 0.8 0.172 14.9 (14.5 – 15.3) 15.8 (14.6 – 16.6) 15.2 (14.5 – 16.6) Hematocrit (%) 48.2 ± 2.0

49.9 ± 2.3 49.0 ± 2.2 0.313   48.0 (46.4 – 50.3) 50.2 (47.2 – 51.8) 49.1 (46.4 – 51.8)   Data are mean ± SD (top row); median and (range) provided in bottom row. Supplementation Ibrutinib Subjects were randomly assigned (via a Block-2 randomization scheme) to ingest MSM at either 1.5 grams per day (n = 4) or 3.0 grams per day (n = 4) for 28 days prior to performing the exercise test, in addition to the two days following the exercise test (i.e., the recovery period).