This means that an undesired sheath breakdown could occur at the vicinities of the nozzle exit even if the average electric field across the
sheath is not strong enough. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3153147]“
“Immunosuppressive treatments used in the management of Inflammatory Bowel Disease, namely steroids, thiopurines and AZD8186 PI3K/Akt/mTOR inhibitor anti-TNF drugs, raise the risk of acquiring opportunistic infections. However, most of these infections are mild and self-limited, not requiring specific therapy or suspension of the immunosuppressors. We report a case of disseminated cutaneous herpes simplex infection in a patient with Crohn’s disease under steroids and azathioprine. (C) 2013 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights
reserved.”
“Background: Evidence buy BYL719 indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD.
Methods: We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patients were followed for 16.2 +/- 15.5 months.
Results: Patients with diabetic glomerulosclerosis had lower urinary miR-15 expression, while those with IgA nephropathy had higher urinary miR-17 expression, than other diagnosis groups. Baseline proteinuria had significant inverse correlation with urinary expression of miR-15, miR-192, and miR-216a; baseline renal function correlated with urinary expression of miR-15, miR-17, miR-192, and miR-217. The rate of renal function decline correlated with urinary expression of miR-21 (r = 0.301, p = 0.026) and miR-216a (r = 0.515, p < 0.0001). Patients with a high urinary expression of miR-21 and miR-216a had better dialysis-free survival than those with low expression (log rank test, p = 0.005 and p = 0.003, respectively).
Conclusions: Urinary miR-21 and miR-216a
expression correlated with the rate of renal function decline and risk of progression to dialysis-dependent renal failure. Our results suggest that urinary miRNA profiling has the potential of further development as biomarkers PFTα molecular weight of CKD.”
“Purpose: We measured the proportion of intravascular leads, which can be extracted by simple traction versus with newer techniques, and examined ‘the overall safety and success rate of lead extractions.
Methods: Between nuary 2005 and December 2007, 311 consecutive patients (mean age = 70 +/- 14 years, 79% men) underwent extractions of 250 atria], 318 ventricular’ and 22 coronary sinus leads, in the surgical facilities of two experienced medical centers, under general anesthesia, at a mean of 7.2 +/- 5.1 years (range 0.1-27.0) after lead implantation. Infection was the indication for extraction in 67.5% of cases. Complementary techniques were used when simple extraction with a locking stylet was unsuccessful.