The theoretical framework is based on a finite time-difference method as applied to a time-dependent Ginzburg-Landau-Devonshire equation. The E7438 domain growth is seen to be of fractal nature, the fractal dimension of which is in good agreement with experiments. When it comes to dynamics we compute the areal velocity of the domain growth as a function of the applied field and find different regions of the nonlinearities that are also in qualitative agreement with experiments. (C) 2010 American Institute
of Physics. [doi: 10.1063/1.3456505]“
“Background
Reduced hemostatic capacity is common following congenital heart surgery using cardiopulmonary bypass (CPB). The etiology is multifactorial with dilutional coagulopathy, as well as platelet adhesion and BI 2536 datasheet activation in the CPB circuit and oxygenator. The purpose of the present study was to evaluate platelet
count and function in children following CPB.
Methods
In a prospective, observational study comprising 40 children, platelet count and function (Multiplate Analyzer((R))) were measured before surgery, immediately after bypass, and on the first postoperative day. Furthermore, conventional coagulation analysis and thromboelastometry (ROTEM (R)) were carried out.
Results
A significant decrease in platelet count was observed immediately after coming of bypass (P<0.001) and persisted to the first postoperative day (P=0.002). Platelet function was reduced immediately after bypass after induction with ADP (P<0.001) or TRAP (P=0.03). The duration of CPB correlated significantly with the decrease in platelet count (r=-0.62, P=0.0001) and reduction in platelet Selleck PR 171 function (r=-0.42-0.63; P<0.01). Moderate to deep hypothermia during CPB was associated with a decreased platelet function (P=0.01-0.12), whereas cyanosis or previous heart surgery caused no further
changes in platelet function following CPB.
Conclusion
Both platelet count and platelet function were significantly reduced after CPB in children undertaken correctional heart surgery. Duration of CPB and hypothermia was associated with significant changes in platelet function.”
“The frequency of delayed function of kidney transplants varies greatly and is associated with quality of graft, donor age and the duration of cold ischemia time. Furthermore, body weight differences between donor and recipient can affect primary graft function, but the underlying mechanism is poorly understood. We transplanted kidney grafts from commensurate body weight (L-WD) or reduced body weight (H-WD) donor rats into syngeneic or allogeneic recipients. Twenty-four hours posttransplantation, serum creatinine levels in H-WD recipients were significantly higher compared to L-WD recipients indicating impaired primary graft function. This was accompanied by upregulation of IL-6 transcription and increased tubular destruction in grafts from H-WD recipients.