strokecenter.org/trials) or geographical region (eg, Pan

African Clinical Trials Registry, www.pactr.org). Researchers often choose to register their trials in their country’s national register, although this is not compulsory. see more It is more important that researchers choose a registry that elicits and documents all the relevant content from the original protocol (outlined below) and that has satisfactory quality, validity, accessibility, unique identification, technical capacity and administration. To assist researchers, the World Health Organization maintains a list of registries that meet these criteria (http://www.who.int/ictrp/network/primary/en/index.html). Currently 16 registries are listed. Among these, researchers could choose

one that processes applications swiftly or that allows communication using their native language. When registering their protocol, researchers will be asked to provide information such as descriptions of the intervention(s) and comparison(s) CP-673451 ic50 studied, study hypotheses, primary and secondary outcomes, eligibility criteria, sample size, blinding, funding, principal investigators, and dates of commencement and anticipated completion of the study. It is common for trial registries to review the information for completeness and clarity, so some editing might be needed. The registry will then provide a unique trial registration number to the researchers. This number should be included in all reports of the trial’s results as a link to the registered protocol for editors, reviewers and readers. Prospective registration can be done any time before the first participant is recruited. Many researchers wait until immediately before Terminal deoxynucleotidyl transferase recruitment starts, so that any late changes to the protocol (such as alterations requested by an ethics committee) do not necessitate an amendment to the registry entry. Although not ideal,

protocol amendments are sometimes made after recruitment starts. These should be updated on the registered protocol as well. The trial registry will publicly document what changed and on what date. The executive of the ISPJE strongly recommends that member journals adopt a policy of mandatory prospective registration for all clinical trials. Several member journals are implementing such policies. Physical Therapy has already implemented a policy of mandatory prospective clinical trial registration, which applies to trials that commenced participant recruitment after 1 January 2009. The following table lists other member journals and their nominated dates to implement mandatory prospective clinical trial registration, as well as the trials that this policy applies to (based on the commencement date of participant recruitment). Table 1. Initiation of the policy of mandatory clinical trial registration by participating journals.