We recorded patient’s full blood count and other biochemistry three months after commencement of dialysis. Correlations between NLR and other metabolic and inflammatory markers were evaluated using Pearson’s r coefficient. The prognostic value of NLR was tested using Kaplan Meier, univariate and multivariate Cox analyses adjusted for Australian and New Zealand Dialysis and Transplant Registry data. Results: 140 haemodialysis patients were included with median follow-up of 36 months and overall mortality of 41% (58
patients). Neutrophil-lymphocyte ratio was positively correlated with C-reactive protein (r = 0.48, P < 0.01) and negatively Staurosporine correlated with haemoglobin (r = −0.32, P < 0.01) and albumin (r = −0.40, P < 0.01). In Kaplan Meier analysis, NLR (stratified into tertiles) was associated with all-cause mortality (log-rank, P = 0.01). In multivariate Cox analysis, NLR was independently
associated with all-cause mortality (HR 1.09, 95% CI 1.01–1.17 P = 0.03). Other predictors of all-cause mortality in multivariate analysis were low albumin (HR 0.89, 95% selleckchem CI 0.89–0.94 P < 0.01) and history of cardiovascular disease (HR 2.29, 95% CI 1.25–4.48 P = 0.01). Conclusions: Neutrophil-lymphocyte ratio correlates with other markers of systemic inflammation in ESKD patients and is associated with poor survival. The extent to which other confounding factors affect these results is unknown. 239 THE RELATIONSHIP BETWEEN PRE-DIALYSIS SERUM AND DIALYSIS FLUID SODIUM CONCENTRATIONS ON HAEMODIALYSIS STABILITY P SAGAR1, S SEN1,2 1Concord Repatriation General Hospital, Concord, NSW; 2University of Sydney, Sydney, NSW, Australia Aim: To audit triclocarban the impact of using a single dialysis fluid sodium concentration across a heterogenous haemodialysis patient population, in regards to hemodynamic instability and interdialytic weight gain (IDWG). Background: The current literature is mixed on the effect of matching pre-dialysis serum sodium concentrations (sNa), to that of the dialysis fluid (dNa). Some studies suggest that
sodium-matched patients have better blood pressure control and lower IDGW. Methods: A retrospective analysis of 72 haemodialysis patients, who were treated with a dNa of 140 mmol/L was performed. Data collected included baseline demographics, comorbidities, average pre-dialysis serum electrolyte concentrations, dialysis prescription, and complication rates over the previous 3 months. Results: The average sNa was 138 (range 129–143), with 75% less than 140 (low), 13% equal to 140 (equal), and 11% greater than 140 mmol/L (high). As sNa increased, there was a non-significant decrease in IDWG (Low 2.0kg, Equal 1.71kgs, High 1.6kg; P = 0.25), and non-significant increases in hypotensive episodes (low 1.9 events/session, equal 0.2, high 0.3; P = 0.55) and requirement to decrease ultrafiltration volume (low 1.2 events/session, equal 0.1, high 0.1; P = 0.52).