We have studied the modification of the Delta(1) and Delta(5) densities of states of Fe1-xMx alloys as a function of the nature of the alloy metal M (M=V, Cr, and Co) and as a function of its chemical content x. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3358608]“
“The Physician Global Assessment (PGA) is a key measure of psoriasis frequently used in clinical trials. A psychometric validation of a three-item (erythema, induration, and scaling) PGA scale was performed using Phase 2 data.

Confirmatory factor analysis (CFA) tested the PGA measurement model and appropriateness of equal weighting of the items.

PGA test-retest reliability was assessed by estimating the intraclass correlation coefficient (ICC). Internal consistency reliability was gauged by calculating Cronbach’s coefficient alpha (CC alpha). Clinically important difference (CID) was CYT387 defined using the repeated measures model to JQEZ5 cell line estimate the relationship between PGA and Patient Global Assessment (PtGA). Known-group, convergent, and divergent validity for the PGA were also assessed.

197 patients with psoriasis were randomized to tofacitinib 2, 5, 15 mg twice daily, or placebo. CFA demonstrated that the PGA measurement model fitted the data using equal weighting of the PGA items. The PGA scale demonstrated good test-retest

reliability (ICC > 0.7) and internal consistency reliability (CC alpha > 0.8). The CID for PGA was estimated at 0.52 (95 % confidence interval: 0.47, 0.56). A robust monotonic relationship

between PGA and Psoriasis Area and Severity Index (PASI) data substantiated known-group validity. Relatively high S3I-201 clinical trial correlations of PGA with PASI and PtGA data (all correlations > 0.5 except at baseline) supported convergent validity; relatively low correlations of PGA with the Pain/Discomfort Assessment and the Ocular Comfort Index supported divergent validity.

The three-item PGA scale has sound psychometric properties with respect to reliability and validity, with equal weighting of the items being appropriate.”
“Objective. The aim of this study was to investigate the apical sealing ability of a newly introduced root canal sealer: iRoot SP Root Canal Sealer.

Study design. Sixty-eight extracted human anterior single-root teeth were used. The coronal part of each tooth was removed and the root canals were prepared with ProTaper files. The specimens were divided into 3 groups of 20 teeth each. Group A specimens were filled with iRoot SP using the continuous wave condensation technique; Group B specimens were obturated with iRoot SP using a single cone technique; Group C specimens were filled with AH plus by means of the continuous wave condensation technique. Evaluation of the apical leakage was performed with a fluid filtration method at 24 hours and 1, 4, and 8 weeks.