We experimentally evaluate the performance of our method CCiMFP on yeast PPI networks. Using gold standard sets of protein complexes, Gene Ontology (GO), and localization annotations, we show that our method gains an improvement over the previous algorithms in terms of precision, recall, and biological significance Selleckchem JNJ-26481585 of the predicted complexes. The colocalization scores of our predicted
complex sets are higher than those of two known complex sets. Moreover, our method can detect GO-enriched complexes with disconnected cores compared with other methods based on the subgraph connectivity.”
“Purpose: Laparoscopic pyeloplasty and open pyeloplasty have comparable efficacy for ureteropelvic junction obstruction in pediatric patients. The role of laparoscopic pyeloplasty in infants is less well defined. We present our updated experience with laparoscopic pyeloplasty in children younger than 1 year.
Materials and Methods: We retrospectively reviewed
the records of all 29 infants treated with transperitoneal laparoscopic pyeloplasty for symptomatic and/or radiographic ureteropelvic junction obstruction from May 2005 to February 2012. Patients were followed with renal ultrasound at regular intervals. Treatment failure was defined as the inability to complete A-1331852 purchase the intended procedure, persistent radiographic evidence of obstruction and/or the need for definitive Bcl-w adjunctive procedures.
Results: Transperitoneal laparoscopic pyeloplasty was performed in 29 infants 2 to 11 months old (mean age 6.0 months) weighing 4.1 to 10.9 kg (mean +/- SD 7.9 +/- 1.6). Followup was available in all except 5 patients (median 13.9 months, IQR 7.7-23.8). Mean operative time was 245 +/- 44 minutes. All cases were completed laparoscopically. Three postoperative complications were reported, including
ileus, superficial wound infection and pyelonephritis. Two patients had persistent symptomatic and/or radiographic evidence of obstruction, and required reoperative pyeloplasty. The overall success rate was 92%.
Conclusions: Laparoscopic pyeloplasty in infants remains a technically challenging procedure limited to select centers. Our early experience revealed a success rate comparable to that of other treatment modalities with minimal morbidity.”
“Recent high-throughput experiments have generated protein-protein interaction data on a genomic scale, yielding the complete interactome for several organisms. Various graph clustering algorithms have been applied to protein interaction networks for identifying protein complexes and functional modules. Although the previous algorithms are scalable and robust, their accuracy is still limited because of the complex connectivity found in protein interaction networks. In this study, we propose a novel information-theoretic definition, graph entropy, as a measure of the structural complexity of a graph.