[2].Analyzing any bio-psycho-social paradigm is complex and needs an extensive, integrative strategy. Parsing the health image of people, as well as entire populations, is not any exclusion. Thinking about maleness as an issue may shed light on wellness standing, specifically since standard some ideas of ‘manhood’ work against health marketing and avoidance, as revealed in researches globally. In fact, these research has revealed a direct organization between traditional understandings of maleness and risks, vulnerabilities together with construction of health. Within the last ten years, such findings have obtained a bit more attention from international agencies.Worldwide, there is a progressive demographic move over the past 50 many years causing a larger proportion of older grownups in the general population. The aging process is a complex biological phenomenon characterized to some extent by alterations in the disease fighting capability referred to as “immunosenescence”, making older grownups more vunerable to infectious, aerobic and autoimmune diseases, also cancers. A few techniques have been suggested in an attempt to reverse immunosenescence, including utilization of hormones, cytokines and thymic facets. A promising drug in the search to replace the thymic microenvironment (which plays a crucial role in the legislation and upkeep regarding the immunity) in older adults is Biomodulina T, a Cuban product licensed for use in clients with recurrent respiratory infections. The management of Biomodulina T advances the quantity of naïve T-lymphocyte, CD4-positive cells that have recently migrated from the thymus gland (present thymic emigrants) and memory CD8-positive T lymphocytes, that have attributes akin to stem cells (stem cell-like memory). Additionally, the phrase of programmed cell demise 1 protein in CD4-positive T lymphocytes and CD4-positive T lymphocytes decreases, therefore the proliferative ability of CD4-positive T lymphocytes increases, without changes in the regularity of regulating T lymphocytes. These results declare that the management of Biomodulina T could possibly be used to displace resistance in older grownups and in other immunocompromised people, enhance response to other immunotherapies in disease clients, and increase the effi cacy of vaccinations in older grownups. Its use happens to be authorized in Cuba for immune protection system restoration.KEYWORDS Immunosenescence, aging, immunotherapy, immuno-modulation, antineoplastic protocols, Cuba.INTRODUCTION The scales offered to predict death and complica-tions after severe coronary problem include angiographic studies and serum biomarkers which are not at your fingertips of solutions with restricted sources. Such services need specifi c and delicate devices to guage risk making use of available resources and information. OBJECTIVE Develop a scale to estimate and stratify the risk of human biology intra-hospital demise in patients with intense ST-segment height myocardial infarction. TECHNIQUES An analytical observational study ended up being conducted in a universe of 769 clients with acute ST-segment level myocardial infarction have been accepted consecutively to the Camilo Cienfuegos Provincial Hospital in Sancti Spíritus Province, Cuba, from January 2013 to March 2018. The fi nal research cohort included 667 patients, ex-cluding 102 due to branch blocks, atrial fi brillation, drugs that prolong the QT interval, low life expectancy or reputation for myocardial infarction. The demographic factors of age, intercourse, pores and skin, classic caose amounts. The variable utilizing the most readily useful predictive capability ended up being cardiorespiratory arrest, followed by a blood sugar degree greater than 11.1 mmol/L. The scale demonstrated a fantastic predictive capability with a detectability index of 0.92. CONCLUSIONS The numeric scale we designed quotes and strati-fi es risk of demise during hospitalization for patients with ST-segment height myocardial infarction and contains good metric properties for predictive ability and calibration. KEYWORD PHRASES ST-segment level myocardial infarction, mortality, threat evaluation, Cuba.INTRODUCTION Antimicrobial drug resistance comprises a health risk of increasing concern worldwide. The most typical av-enues for the acquisition of clinically-relevant antimicrobial weight could be tracked back again to the food offer, where opposition is obtained through the ingestion of antimicrobial resistant microorganisms pres-ent in food. Antimicrobial weight constitutes a health danger, causing manufacturing losses and unfavorable consequences for livelihood and food security. OBJECTIVE see whether resistant germs are present in meals in Cuba. METHODS A descriptive observational study ended up being carried out in theMicrobiology Laboratory of Cuba’s nationwide Institute of Hygiene, Epi-demiology and Microbiology from September 2004 through Decem-ber 2018. Scientists analyzed 1178 bacterial isolates from food examples. The isolates were identifi ed as Escherichia coli, Salmonella, Vibrio cholerae and coagulase-positive Staphylococcus. The antimi-crobial susceptibility research was carried out using the Bauer-Kirby disk diffusion technique, following procedures outlined by the Clinical and Laboratory guidelines Institute. The info were analyzed making use of WHO-NET version 5.6. Link between the total isolates, 62.1% were resistant to at least one antibiotic drug. Within each group, >50% of isolates revealed some sort of weight. E. coli and V. cholerae exceeded 50% opposition to tetracycline and ampicillin, respectively.