The sites of active disease were in the liver in 10 patients, mesentery kinase inhibitor Veliparib in three, pararectal region in three, stomach in three, and one each in the peritoneum, lymph nodes, retroperitoneum and bone. Ten patients (59%) had initial metastatic disease, three (17.5%) had recurrent disease, three (17.5%) had no free surgical margin, and one (6%) had unresectable advanced disease. Overall response correlating with patterns of CT change At the end of study, there were eight non-responders and nine responders. Non-responders consisted of two live and six dead patients. The median time of follow up was 11 mo (range 3-29 mo). The majority of active disease was found to be located in the liver, with a minority in the mesentery, retroperitoneum and bone. All patients developed the GP pattern at the end of follow up.

Two patients developed FP, whereas one developed NS. One of the FP patients showed initial GC and NC. For one patient who had active sites in the liver and mesentery, GP was observed in the mesentery, while the liver lesions showed a GC pattern. The remainder of GP and NS had the same pattern throughout till the end. The median time to GP was 5.5 mo (range 2-23 mo). However, one patient showed GP after a prolonged 23 mo of SD and had early initial NC. There were nine responders. They showed GC, NC, and response according to RECIST criteria in five, one and three patients at the end of study, respectively. The active sites of GC were in the liver (one patient), pararectum (two), and one each in the stomach and peritoneum/intra-abdominal nodes. One patient showed NC in the liver.

The median time to GC and NC was 3.5 mo (range 2-8 mo). Of the three patients with no change in pattern, two patients had a change in size only (PR and CR within the RECIST criteria), while the third patient showed a slight decrease in size (SD). The patient with CR had an active site in the stomach (no free margin in surgery) without metastasis, and the time to CR was 4 mo. The SD patient had an active site in the mesentery. Half of the responders showed PR in the initial follow up. Survival data analysis according to patterns of CT change Complete information on the patients�� clinical course of imatinib treatment was obtained in 17 cases. Median follow-up time was 15 mo (range 3-29 mo). Survival status was alive in 11 (64.7%) and dead due to disease in six (35.3%).

Median overall survival time of the patients after imatinib treatment was 19 mo (95% CI, 9.3-80.5). Overall survival was better in GC/NC and CR/PR/SD (response according Carfilzomib to RECIST) compared with GP patients, and P was 0.0271 (Table (Table1,1, Figure Figure66). Table 1 Median survival time according to pattern of CT change Figure 6 Overall survival after imatinib therapy, according to the patterns of CT change.