Several antiviral medicines, that target various stages of viral reproduction, have been considered efficient when it comes to treatment and avoidance of influenza, but some virus strains become resistant to these medications. Hence, brand new methods and techniques must be developed to conquer the antiviral medicine weight. Current researches suggest that brand-new medications based on RNA disturbance (RNAi) seem to be a promising therapeutic approach that regulates the activity of viral or cellular genes. As it is well known, the RNAi is a eukaryotic gene regulating method which can be set off by a foreign double-stranded RNA (dsRNA) and results in the cleavage associated with target messenger RNA (mRNA). This review discusses the leads, advantages, and disadvantages of using RNAi in carrying out a particular treatment plan for influenza infection. Nonetheless, some viruses confer resistance to tiny interfering RNAs (siRNA) targeting viral genetics. This issue can considerably reduce steadily the effectiveness of RNAi. Consequently, applying siRNAs targeting host cell facets needed for influenza virus reproduction are a method to overcome the antiviral drug opposition..This review article views the possibilities of combined antiviral therapy when you look at the remedy for clients with COVID-19, in line with the analysis associated with the device of action of known antiviral drugs into the framework for the health hypothesis. The potential effectiveness for the shared utilization of viral RNA polymerase inhibitors and a fusion inhibitor in this pathology is discussed. The review covers the primary associates of those sets of medicines – ribavirin, riamilovir, umifenovir, favipiravir. The efficacy and protection profile of the medications biohybrid system ended up being reviewed, including the connection with their particular SHP099 use within clinical tests food as medicine carried out during the COVID-19 pandemic, also earlier work performed during the SARS and MERS epidemics.It has been founded that bloodstream are target for influenza, but the device by which the influenza virus impacts the heart is unidentified. The goal – version of influenza virus A/St. Petersburg/48/16 H1N1(pdm09) to mature Wistar rats, as these creatures will be the primary experimental design for learning the pathology regarding the heart. The information obtained allow us to close out that the stress of influenza virus A/St. Petersburg/48/16 H1N1(pdm09) had been adapted to mature Wistar rats maintaining virulent properties. The infectious titer for the virus in the final phase of version had been 7.0 lg EID50/ml. IAV identification is verified by immunohistochemical evaluation.The information received allow us to conclude that the stress of influenza virus A/St. Petersburg/48/16 H1N1(pdm09) had been adjusted to grow Wistar rats keeping virulent properties. The infectious titer associated with virus during the final phase of adaptation had been 7.0 lg EID50/ml. IAV recognition is confirmed by immunohistochemical examination. Influenza is a severe viral disease, a frequent problem of that will be a secondary bacterial pneumonia. Influenza vaccines avoid secondary microbial complications. Virus-like particles tend to be one of the encouraging areas when it comes to growth of new vaccines. The goal of this tasks are to study the correlation for the pathomorphological qualities for the lungs with clinical, virological, and microbiological markers regarding the disease at vaccination with virus-like particles (VLPs), containing hemagglutinin (HA) of influenza virus (HA-Gag-VLPs) in a murine type of additional microbial pneumonia caused by S. pneumoniae after influenza disease. This article gift suggestions the outcome regarding the initial study, the purpose of that was to review the prevalence of antibodies to parvovirus B19 in addition to task associated with circulation with this virus in socially crucial categories of the population. Materials associated with the research were blood samples from blood donors of Saint Petersburg, along with parvovirus В19 sequences isolated from DNA-positive plasma examples. In accordance with the link between the laboratory examination, a higher percentage of companies of virus-specific IgG antibodies had been found in studied group of donors, which confirms the previous disease of parvovirus B19 in them and illustrates the high prevalence of infection in this socially significant group. Based on the outcomes ofults of the study, it is warranted to include evaluating of blood samples for markers of В19 parvovirus infection in present formulas of laboratory study of donors, that will make sure prevention of hemo-contact infection of blood recipients with parvovirus В19. The diagnostic effectiveness of means of hepatitis E serodiagnostic varies over a variety; therefore, the combined use of tests of various formats is recommended. The aim of the research would be to develop a test system when it comes to recognition of IgG antibodies to hepatitis E virus (HEV) in individual serum by linear immunoassay (LIA). Serum samples from patients with hepatitis and healthier individuals had been tested utilizing commercial enzyme-linked immunosorbent assay systems for the existence of IgG antibodies to viral representatives causing hepatitis and other infections connected with liver pathology. Recombinant antigens ORF2 and ORF3 of HEV genotypes 1 and 3 were used.