The complex relationship between probiotics and polyamines as wel

The complex relationship between probiotics and polyamines as well as the role played by these amines in maintenance of intestinal epithelial integrity justify further studies. Research will be addressed to investigate the role of polyamines by evaluating not only the enzymes involved in the regulation of their production and degradation, but also considering in vivo study LY2606368 in vitro design on animal model of gluten-sensitive enteropathy [48]. Acknowledgements Authors thank Dr. Benedetta D’Attoma for her precious technical assistance. References 1. Green PHR, Cellier C: Celiac disease. N Engl J Med 2007,357(17):1731–1743.PubMedCrossRef

2. Mettner J: Gluten and the gut. Minn Med 2012,95(12):14–18.PubMed 3. Dieterich W, Esslinger B, Schuppan D: Pathomechanisms in celiac disease. Int Arch

Allergy Immunol 2003,132(2):98–108.PubMedCrossRef 4. Heyman M, Abed J, Lebreton C, Cerf-Bensussan N: Intestinal permeability in celiac disease: insight into mechanisms and relevance to pathogenesis. Gut 2012,61(9):1355–1364.PubMedCrossRef Erastin 5. Liu Y, Nusrat A, Schnell FJ, Reaves TA, Walsh S, Pochet M, Parkos CA: Human junction adhesion molecule regulates tight junction resealing in epithelia. J Cell Sci 2000,113(Pt 13):2363–2374.PubMed 6. TPCA-1 nmr Assimakopoulos SF, Papageorgiou I, Charonis A: Enterocytes’ tight junctions: from molecules to diseases. World J Gastrointest Pathophysiol 2011,2(6):123–137.PubMedCentralPubMedCrossRef 7. Al-Sadi Interleukin-3 receptor R, Khatib K, Guo S, Ye D, Youssef M, Ma T: Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 2011,300(6):G1054-G1064.PubMedCrossRef 8. Zeissig S, Bürgel N, Günzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD: Changes in expression and distribution of claudin 2,5,

and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease. Gut 2007,56(1):61–72.PubMedCrossRef 9. McCall IC, Betanzos A, Weber DA, Nava P, Miller GW, Parkos CA: Effects of phenol on barrier function of a human intestinal epithelial cell line correlate with altered tight junction protein localization. Toxicol Appl Pharmacol 2009, 241:61–70.PubMedCentralPubMedCrossRef 10. Assimakopoulos SF, Tsamandas AC, Tsiaoussis GI, Karatza E, Triantos C, Vagianos CE, Spiliopoulou I, Kaltezioti V, Charonis A, Nikolopoulou VN, Scopa CD, Thomopoulos KC: Altered intestinal tight junctions’ expression in patients with liver cirrhosis: a pathogenetic mechanism of intestinal hyperpermeability. Eur J Clin Invest 2012,42(4):439–446.PubMedCrossRef 11. Thomas T, Thomas TJ: Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci 2001, 58:244–258.PubMedCrossRef 12.

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