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“Purpose Health-related quality of life (HRQOL) is not only a degree of health find more but also reflects patient perceptions and expectations of health. For children with brain tumors, better understanding of HRQOL requires the use of complementary reports from parents and interviewer-administered reports for children. Here, we aimed to test whether or not the trait anxiety of children and the psychological distress of their parents influence children’s and parents’ responses to HRQOL

questionnaires, and whether or not the report-administration method for children influences children’s responses to HRQOL questionnaires.

Methods One hundred and thirty-four children aged 5-18 with brain tumors and one of their parents completed the Pediatric Quality of Life Inventory (TM) (PedsQL (TM)) Brain Tumor Module questionnaires. In addition, the children also completed the State-Trait Anxiety Inventory for Children (STAIC), and the parents also completed the Kessler-10 (K10) and health and sociodemographic characteristics questionnaires. The child questionnaires were administered either by the child (self-administered) or an interviewer. Rater-dependent VX-765 concentration perceptions about HRQOL were derived from the subscales scores of the PedsQL (TM) Brain Tumor Module using structural equation

modeling based on a multitrait-multimethod model. The STAIC trait-anxiety score, K10 score, report-administration method, and other health and sociodemographic factors related to each child’s or parent’s perceptions were identified through multiple linear regression analyses of the questionnaire responses. We used a path analysis to estimate the change in a PedsQL (TM) child-reported score that occurs when interviewer-administration changes the child’s perception about HRQOL.

Results Surveys for 89 children were self-administered while those for 45 were interviewer-administered. The perceptions of the children

and parents were calculated by fitting data to the model (chi-squared P = 0.087, normed fit index = 0.932, comparative fit index = 0.978, standardized root mean squared see more residual = 0.053, and root mean square error of approximation = 0.054). The children’s perception of HRQOL was affected by their STAIC trait-anxiety score (b = -0.43, 95% CI [-0.60, -0.25]). The parent’s perception was affected by their child’s treatment status (b = 0.26, 95% CI [ 0.09, 0.43]), the parent’s K10 score (b = -0.21, 95% CI [-0.37, -0.04]), and by education level (b = 0.17, 95% CI [ 0.00, 0.34]). The change in the child-reported PedsQL (TM) score in relation to the method of administration ranged from -1.1 (95% CI: -3.5, 1.3) on the procedural anxiety subscale to -2.5 (95% CI: -7.6, 2.6) on the movement and balance subscale.

Conclusion Child-reporting of HRQOL is little influenced by the method of administration.