“
“Objective.— To investigate bilateral widespread pressure pain hyperalgesia selleck kinase inhibitor in deep tissues over symptomatic (trigemino-cervical) and nonsymptomatic (distant pain-free) regions in patients with cluster headache (CH). Background.— Central sensitization is claimed to play a relevant role in CH. No study has previously searched for widespread pressure hyperalgesia in deep tissues over both symptomatic (trigemino-cervical) and nonsymptomatic (distant pain-free) regions in patients with CH. Methods.— Sixteen men (mean age: 43 ± 11 years) with CH in a remission phase and 16 matched controls were recruited. Pressure pain thresholds (PPTs) were bilaterally measured over the supra-orbital
(V1), infra-orbital (V2), mental (V3), median (C5), radial (C6), and ulnar (C7) nerves, C5-C6 zygapophyseal joint, mastoid process, and tibialis anterior muscle by an assessor blinded to the subjects’ condition. Results.— The results showed Dinaciclib that PPT levels were significantly decreased bilaterally in patients with CH as compared with healthy controls (all sites, P < .001). A greater degree of sensitization over the mastoid process (P < .001) and a lower degree of sensitization over the tibialis anterior muscle (P < .01) was found. Conclusions.— Our findings revealed bilateral widespread pressure pain hypersensitivity in patients with CH confirming the presence
of central sensitization mechanisms in this headache condition. “
“Migraine is generally recognized as a complex condition, which is often challenging to treat. Patients are often open to novel approaches to understanding why this pain occurs and how to prevent future attacks. Ayurvedic medicine, which is a 5000-year-old healing system, offers additional understanding on this disease by categorizing patients into a unique dosha (mind–body) type. Specific herbals, dietary modifications, and lifestyle changes have been utilized for thousands of years to create balance in
the system to improve chronic conditions. Evaluating migraine patients utilizing the Ayurvedic model allows patients and practitioners a further layer of understanding and offers additional treatment options for the patient. Ayurveda is recognized as one of the oldest healing systems Cobimetinib datasheet known to mankind. Ayurveda is a Sanskrit word which literally means “the science” of life. This is the knowledge of health and disease predisposition based on understanding oneself as an individual in an environment that is constantly influencing us to shift and change from our baseline state of balance. Our current Western, allopathic, view of medicine is to base treatment on presenting symptoms. Medications and injectables are often used to treat the symptoms, allowing relief of the symptoms at hand. Preventive medications are given to decrease the severity of disease and give relief of acute symptomatology. The Eastern, specifically Ayurvedic, approach offers a layer on the allopathic model.