Methods: From December 2010 to December 2012, there were 45 patients underwent intranperative perforation during ESD of grastic submucosal lessions. We

reviewed and recorded the respiratory and circulatory index including End-tidal carbon dioxide concentration (EtCO2), arterial oxygen pressure (PaO2), arterial carbon dioxide pressure (PaCO2), Peak airway pressure (PPEAK), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), electrocardiogram (ECG), heart rate (HR) and oxygen saturation of arterial blood (SpO2) before and after perforation. Results: The R788 chemical structure value of EtCO2, PaCO2, PPEAK, MAP and HR increased significantly after perforation. Conclusion: Intranperative perforation during ESD of grastic submucosal Atezolizumab purchase lessions had obvious effect on respiratory and circulatory function. Thus, respiratory and circulatory index should be under close monitoring to ensure the safety of ESD. Key Word(s): 1. endoscopic; 2. ESD; 3. perforation; Presenting Author: LIBIN HUANG Additional Authors: ZHIYIN HUANG, PU WANG, YOUPING LI, XIANGLIAN LI, JIANTONG SHEN, CHENGWEI TANG Corresponding Author: LIBIN HUANG Affiliations: West China Hospital Objective: The aim of this study

was to assess the accuracy, safety and economics of capsule endoscopy (CE) for the diagnosis of small bowel diseases (SBD). Methods: According to the principles of health technology assessment (HTA), we searched some important medical databases including Health Technology Assessment Database (INAHTA), Cochrane Library, PubMed, Embase, VIP database, Chinese biomedical literature database (CBM) and Chinese Journal full-text database (CNKI) until July, 2012. Liothyronine Sodium We reviewed and evaluated the diagnostic characteristics of CE. Results: Out of 2246 preliminary

relevant papers, 31 papers (4 HTA, 12 SR, 10 economics, 3 guidelines and 2 RCT) were included in this study. Most of them were carried out in patients with obscure gastrointestinal bleeding (OGIB), Crohn’s disease (CD) and Celiac disease. The visualization of the small bowel to the cecum was achieved in approximately 80% of the patients. The reported diagnostic yield ranged from 39% to 83%, sensitivity from 80% to 95% and specificity from 75% to 100%. Few patients (0.9%∼5.2%) were recorded adverse events, and most patients alleviated spontaneously with no treatment. Capsule retention only occurred in 0.3%∼3.0% of the patients. The costs used in CE diagnostics were calculated as an average of the declared values in 3 out of 4 HTA studies. It was reported by HTA in Italy that the higher the number of annual CE examinations, the lower the unit cost of the procedure.