In this review, we describe the most recent developments in non-covalent molecularly-imprinted polymers (MIPs) to replace natural receptors in ligand-binding assays and biosensors. A key factor underpinning the most significant advances in this field is obtaining materials that improve the specific recognition and, at
the same time, favor transduction.
Composites of MIPs and carbon nanostructures or inorganic nanoparticles combine the recognition properties of MIPs with the electrical, optical or magnetic properties of the nanomaterials, resulting in new imprinted nanoreceptors with great potential as sensing materials. 3-Methyladenine ic50 We summarize various methods to blend MIPs with different nanomaterials and highlight their application in biomimetic assays.
Electropolymerized MIPs (E-MIPs) offer an option for integrating the recognition elements as nanofilms on the surface of different transducers. We discuss recent advances in the use of E-MIPs for analytical applications.
MIPs SNX-5422 order mimicking natural enzymes are also among these new functional materials. We present the approaches to prepare catalytic non-covalent MIPs along with recent analytical applications and challenges for future developments. (C) 2012 Elsevier Ltd. All rights
reserved.”
“Green synthesis of selenium nanoparticles (SeNPs) was achieved by a simple biological procedure using the reducing power of fenugreek seed extract. This method is capable of producing SeNPs in a size range of about 50-150 nm, under ambient conditions. The EVP4593 clinical trial synthesized nanoparticles can be separated easily from the aqueous sols by a high-speed centrifuge. These selenium nanoparticles were characterized by UV-Vis spectroscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and elemental analysis by X-ray fluorescence spectrometer (XRF). Nanocrystalline SeNPs were obtained without post-annealing treatment. FTIR spectrum confirms the presence of various functional
groups in the plant extract, which may possibly influence the reduction process and stabilization of nanoparticles. The cytotoxicity of SeNPs was assayed against human breast-cancer cells (MCF-7). It was found that SeNPs are able to inhibit the cell growth by dose-dependent manner. In addition, combination of SeNPs and doxorubicin shows better anticancer effect than individual treatments.”
“Objective: To evaluate outcomes associated with insulin therapy disruption after hospital discharge in patients with type 2 diabetes mellitus who had used insulin before and during hospitalization.
Methods: In this observational, retrospective analysis of medical records obtained from a coordinated health system in the United States, patients with type 2 diabetes mellitus who had used insulin 30 days before and during hospitalization were included.