(C) 2010 American Institute of Physics. [doi:10.1063/1.3456493]“
“BACKGROUND: The year 2009 was notable for the outbreak of a novel strain of influenza A (H1N1). We report the outcomes of H1N1 infection in a large cohort of lung transplant (LTx) recipients and candidates.
METHODS: This was a retrospective review of 22 suspected cases
of H1N1 influenza screened using real-time polymerase chain reaction from nasal secretions. There were 15 confirmed cases (10 LTx recipients, 5 LTx candidates).
RESULTS: All patients were treated with oseltamivir at the time of the first clinical assessment. In the LTx recipients group, 7 of the 10 confirmed cases were treated at home with oseltamivir alone. Three patients were admitted with complications (2 pneumonia, 1 acute rejection). Two patients required mechanical ventilation. Two patients
had prolonged viral shedding. No deaths occurred among the LTx recipients. In the Bafilomycin A1 clinical trial 5 LTx candidates with confirmed H1N1, LBH589 research buy 2 deaths occurred from pneumonia and acute respiratory distress syndrome.
CONCLUSIONS: Influenza H1N1 had a significant complication rate amongst LTx recipients and a high mortality rate amongst LTx candidates. J Heart Lung Transplant 2010;29:1034-8 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved.”
“Purpose The KIDSCREEN questionnaires were developed by a collaborative effort of European pediatric researchers for use in epidemiologic public health surveys, clinical intervention studies, and research projects. The article gives an overview of the development of the tool, summarizes its extensive applications in Europe, and describes the development of a new computerized adaptive test (KIDS-CAT) based on KIDSCREEN experiences.
The KIDSCREEN
versions (self-report and proxy versions with 52, 27, and 10 items) were simultaneously developed in 13 different European countries to warrant cross-cultural buy Buparlisib applicability, using methods based on classical test theory (CTT: descriptive statistics, CFA and MAP, internal consistency, retest reliability measures) and item response theory (IRT: Rasch modeling, DIF analyses, etc.). The KIDS-CAT was developed (in cooperation with the US pediatric PROMIS project) based on archival data of European KIDSCREEN health surveys using IRT more extensively (IRC).
Research has shown that the KIDSCREEN is a reliable, valid, sensitive, and conceptually/linguistically appropriate QoL measure in 38 countries/languages by now. European and national norm data are available. New insights from KIDSCREEN studies stimulate pediatric health care. Based on KIDSCREEN, the Kids-CAT promises to facilitate a very efficient, precise, as well as reliable and valid assessment of QoL.
The KIDSCREEN has standardized QoL measurement in Europe in children as a valid and cross-cultural comparable tool.