Among the identified aerobic gram-negative isolates, there were 25 isolates of Pseudomonas BMS202 manufacturer aeruginosa, comprising 5.5% of all identified aerobic bacteria isolates. Among the identified aerobic gram-positive bacteria, Enterococci (E. faecalis and E. faecium) were the most prevalent, representing 10.5% of all aerobic isolates, 3 glycopeptide-resistant Enterococci were identified; 2 were glycopeptide-resistant Enterococcus faecalis isolates and 1 was glycopeptide-resistant
Enterococcus faecium isolates. Tests for anaerobes were conducted for 168 patients. 52 anaerobes were observed. The most frequently identified anaerobic pathogen was Bacteroides. 39 Bacteroides isolates were observed during the course of the
study. Additionally, 36 Candida isolates were collectively identified. 30 were Candida albicans and 6 were non-albicans Candida. Outcome The overall mortality rate was 10.1% (71/702). 68 patients (9.7%) were admitted to the intensive care unit in the early Rabusertib ic50 recovery phase immediately following surgery. 90 patients (12.8%) ultimately required additional surgeries; 54% of these BAY 11-7082 in vitro underwent relaparotomies “on-demand”, 28.9% underwent open abdomen procedures. According to univariate statistical analysis, a critical clinical condition (severe sepsis and septic shock) upon hospital admission was the most significant risk factor for death; indeed, the rate of patient mortality was 36.6% (41/112) among critically ill patients (patients presenting
with septic shock and severe sepsis upon admission), but the mortality rate was only 5.1% (30/590) for clinically stable patients (p < 0.0001). For patients with generalized peritonitis, the mortality rate was 18% (55/304) while patients with localized peritonitis or abscesses demonstrated a mortality rate of only PTK6 4% (16/398) (p < 0,001). The immediate post-operative clinical course was a significant parameter for predicting mortality: the rate of patient mortality was 54.9% (51/93) among critically ill patients (patients presenting with septic shock and severe sepsis upon the immediate post-operative course), but the mortality rate was only 3.3% (20/609) for clinically stable patients (p < 0.0001). Preliminary statistical analyses were performed using MedCalc® statistical software. Conclusion Complicated intra-abdominal infections remain an important cause of morbidity with poor clinical prognoses. The purpose of the CIAOW Study is to describe the epidemiological, clinical, microbiological, and treatment profiles of both community-acquired and healthcare-acquired complicated intra-abdominal infections (IAIs) based on the data collected over a six-month period (October 2012 to March 2013) from 56 medical institutions Worldwide. The final results of the CIAOW Study will be published following the conclusion of the study period in March 2013. References 1.