4,11–19 Table 3 Reported Regional Kidney Stone Prevalence Rates per Country and Year In countries reporting prevalence rates in the 1980s and 1990s, the nonweighted, average global prevalence was 3.25% in the 1980s and 5.64% in the 1990s.3–7,9,10 The highest prevalence rates across all reports were for uranium workers in eastern Tennessee (18.5%) and adults in Northeast Thailand (16.9%) (Table 3).15,19 http://www.selleckchem.com/products/Trichostatin-A.html incidence In the United States, overall Inhibitors,research,lifescience,medical incidence increased during 1971 to 1978.1,20 In the year 2000, an incidence of 1116 per 100,000 was reported for 18- to 64-year-old employees covered

by 2 large insurance sellekchem carriers.21 This incidence is significantly higher than those from the aforementioned periods. Studies performed in Rochester, MN, showed a steady incidence increase from the 1950s Inhibitors,research,lifescience,medical through

1990, with a drop somewhat in 2000.22,23 In Japan, the incidence of nephrolithiasis has doubled over a 40-year time Inhibitors,research,lifescience,medical period, both in men and women. These increases were most prominent in the last 10 to 20 years, with rates among men increasing sharply since the 1990s, and rates among women increasing more gradually since the 1980s.24–26 Countries or regions reporting incidence rates for only 1 year include Seoul, Korea, and 4 Spanish cities (Granada, Tudela, Marina Alta, Saragossa)4,16 (Table 4). Table 4 Reported Regional Kidney Stone Incidence Inhibitors,research,lifescience,medical Rates per Country and Year Sex and Age Iran, Japan, and the United States had stone incidence reports stratified by age22–24,27 (Figures 1–3). Incidence rates reported by age group consistently show a rise-and-fall pattern as a population ages. Age at peak incidence Inhibitors,research,lifescience,medical was similar among these 3 countries: Age at peak incidence was similar among these 3 countries, ranging from 40 to 49 years, except for Japanese women for whom the peak incidence occurred between ages

50 to 59 years. The actual incidence rate was similar for men age 40 to 49 years in the United States and Japan but lower in Iran. Figure 1 2005 Iran kidney stone incidence by age group. A rise-and-fall pattern is observed Batimastat for reported incidence rates in Iran during 2005. Peak incidence is observed in the 40- to 49-year-old age group. Stone prevalence increased with increasing age in Germany, Iceland, Iran, Italy, Greece, Turkey, and the United States (Figures 4–10), although there is a sharp decrease in prevalence in Italians, age > 60 years, living in Milan2,5,7,11,12,14,27(Figure 11). In Korea, prevalence rates decreased as men aged, but increased in women and peaked at age 60 to 69 years16 (Figure 12).