20% and 50% DRZ loading showed the highest entrapment efficiency for OCM-CSNs and CSNs, respectively. Entrapment efficiency of DRZ with synthesized OCM-CS
improved by 14% compared to CS. In vitro release profile showed sustained release over the period of 8h for OCM-CSNP. In vitro mucoadhesion studies showed enhanced mucoadhesion of OCM-CSNPs compared to CSNPs. Prepared OCM-CSNPs Inhibitors,research,lifescience,medical were nonirritant when tested by HET-CAM. In vivo studies of DRZ loaded OCM-CSNPs exhibited a promising prolonged antiglaucoma effect without pulse entry as compared to CSNPs. The currently resultant OCM-CSNPs had better entrapment, tailored drug release, and improved bioavailability with reduction in pulse entry as compared to CSNPs. Hence it can be concluded that DRZ loaded OCM-CSNPs is better and efficacious alternative to conventional eye drops for the anti-glaucoma activity. Inhibitors,research,lifescience,medical Conflict of interests The authors declare that they have no conflict of interests in this work. Acknowledgments The authors are thankful to TIFR, Mumbai, India for X-ray diffraction, Nair Hospital, Mumbai, India for HET-CAM and IIT Bombay, India for TEM studies.
Gliomas account for Inhibitors,research,lifescience,medical almost all primary tumors in the central nervous system
(CNS) among which glioblastoma multiforme (GBM) is the most malignant and invasive. In spite of some therapeutic improvements from neurosurgery, radiation therapy, and pharmacology, the 5-year median survival rate is less than 5%, which clearly justifies attempts to improve treatment. The Inhibitors,research,lifescience,medical epidermal growth factor receptor (EFGR) is a transmembrane glycoprotein with its intracellular domain acting as a tyrosine kinase and its extracellular part acting as a receptor with high affinity for EGFR [1]. EGFR is highly expressed in cancer
Inhibitors,research,lifescience,medical cells in more than 40% of GBM cases, and the mutated form of EGFR, EGFRvIII, is additionally expressed in more than 40% of GBM cases expressing EGFR [2, 3], clearly indicating that EGFR could play a role in GBM pathogenesis. Furthermore, as EGFR and EGFRvIII are substantially expressed by the leave a message cancer cells in GBM, these receptors are amendable for targeted therapy [4]. Liposome-based Carfilzomib therapeutics are usable for treatment of a variety of cancer types, but current available liposomes for human use are not provided conjugated with targeting molecules, which increases the demand for dosage to reach a therapeutic acceptable concentration near the cancer cells and also increases the risks of side effects [5]. Accordingly, target-based therapeutics consisting of protein ligands or antibodies conjugated to liposomes are widely investigated for drug delivery to cancer cells specifically expressing certain proteins adaptable for targeting.