1063/1.3540410]”
“To obtain ideal liquid bandage polymer materials, a series of polyurethane-urea dispersions were synthesized from 4,4′-diisocyanato dicyclohexylmethane (H12MDI) and ethylene diamine with different molar ratio of polyol blend [polyethylene glycol (PEG, M-n = 2000 g/mol)/hydroxy terminated poly(dimethylsiloxane) (PDMS, M-n = similar to 550 g/mol)] and acetone/ethanol as a solvent. The effect of PDMS content
in PEG/PDMS on the viscosity, mechanical properties, water contact angle/surface check details energy, insolubility in water (%), water absorption (%), equilibrium water content (%), and water vapor transmission rate (g m(-2) day(-1)) of polyurethane-urea films was investigated. As PDMS content increased, the water contact angle, insolubility in water, and tensile strength/elastic recovery of film sample increased; however, the surface energy, water absorption (%), equilibrium water content (%), and water vapor transmission rate (g m(-2) day(-1)) of film sample decreased. By a wound-healing evaluation using a full-thickness rat model experiment, it was found that a wound covered with a typical polyurethane-urea liquid bandage film (PD2 sample) was filled with new epithelium without any significant
adverse reactions. These results suggest that the polyurethane-urea-based liquid bandages (samples: PD2 and PD3) prepared in this study may have high potential as new wound dressing materials, which provide and maintain the adequate wet environment required to prevent scab formation and dehydration of the wound bed. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 3516-3524, 2011″
“Purpose: BGJ398 price To investigate alterations in functional connectivity in the resting brain networks in healthy elderly volunteers and patients with mild, moderate, or severe Alzheimer Disease (AD).
Materials and Methods: This study was approved by the institutional ethics committee, and informed consent was obtained. Forty-six patients with AD and 16 healthy elderly volunteers were prospectively examined. Resting-state
functional magnetic resonance imaging was used to detect alterations in posterior cingulate cortex (PCC) functional connectivity through a comparison of the healthy control group with three separate AD groups-mild, moderate, and severe AD. A temporal selleck products correlation method was used to obtain PCC connectivity maps.
Results: Dissociated functional connectivity between the PCC and a set of regions, including the visual cortices bilaterally, the inferior temporal cortex, the hippocampus, and especially the medial prefrontal cortex and the precuneus and/or cuneus, was observed in all AD groups. The disruption of connectivity intensified as the stage of AD progression increased. There were also regions that exhibited increased connectivity; these regions extended from left lateralized frontoparietal regions and spread to bilateral frontoparietal regions along with AD progression.