05). Nausea, emesis, fatigue, dehydration, and hyponatremia also were more frequent with vorinostat.\n\nConclusion\n\nVorinostat

enhances the efficacy of carboplatin and paclitaxel in patients with advanced NSCLC. HDAC inhibition is a promising therapeutic strategy for treatment of NSCLC.”
“The effect of high air relative humidity (RH) cycling (RHC 62%/100%) on the degradation mechanisms of a single (5 x 5?cm2) proton exchange membrane fuel cells was investigated. The cell performance was compared to a cell operated at constant humidification (RHC?=?62%). Runs were conducted over approximately 1,500?h at 0.3?A?cm2. The overall loss in cell performance for the high RH cycling test was 12 mu V?h1 whereas it was at 3 mu V?h1 under constant humidification. Impedance

spectroscopy reveals that the ohmic and charge transfer resistances were little modified in both GSK1904529A in vitro runs. H2 crossover measurement indicated that both high RH cycling and constant RH test did not promote serious effect on gas permeability. The electroactive surface loss for anode and cathode during high air RH cycling was more significant than at constant RH operation. The water uptake determined by 1H nuclear magnetic resonance within the membrane electrode assembly (MEA) after high RH cycling was reduced by 12% in comparison CYT387 clinical trial with a fresh MEA. Transmission electron microscopy showed bubbles and pinholes formation in the membrane, catalyst particles agglomeration RG-7112 clinical trial (also observed by X-ray diffraction), catalyst particles migration in the membrane and thickness reduction of the catalytic layers.

Scanning electron microscopy was conducted to observe the changes in morphology of gas diffusion layers after the runs.”
“Objectives To assess the influence of subjective word-finding difficulty on degree of engagement in social leisure activities among individuals with Alzheimer’s disease (AD). Design Analysis of data collected from the second cohort of the Multicenter Study of Predictors of Disease Course in Alzheimer’s disease. Setting Four study sites in the United States and France. Participants Individuals diagnosed with mild to moderate AD (N=236). Measurements On separate questionnaires, participants were asked to 1) report whether they had trouble finding the right word when speaking (subjective word-finding difficulty) and 2) rate their frequency and enjoyment of social and nonsocial leisure activities. Objective language measures included object naming and verbal fluency. Measures of dependence, depression, cognitive status, age, sex, and education were also included as covariates in regression analyses. Results Fifty-two percent of the sample reported word-finding difficulty, and subjective complaints were correlated with poorer verbal fluency scores. Subjective word-finding difficulty was selectively related to social but not nonsocial activity measures.