Clinical relevance was assessed via error grid analysis.
Results-Although correlation between results of both PBGMs and the standard analyzer was >0.90, disagreement was greater than could be explained by instrument imprecision alone. Mean difference between PBGM-H and chemistry-analyzer values was -15.8 mg/dL. Mean difference between PBGM-D and chemistry-analyzer values was 2.4 mg/dL. Linear regression analysis revealed proportional bias of PBGM-H
(greater disagreement at higher glucose concentrations); no proportional bias was detected for PBGM-D. No constant bias was detected for either PBGM. Error grid analysis revealed all measurements from both PBGMs were within zones without an anticipated
NCT-501 Metabolism inhibitor effect on clinical outcome.
Conclusions and Clinical Relevance-Neither PBGM had exact agreement with the automated analyzer; however, the disagreement detected did not have serious clinical consequences. Our findings stressed the importance of using the same device for monitoring trends in dogs and using instrument-specific reference Wnt pathway ranges. (J Am Vet Med Assoc 2009;235:1309-1313)”
“In a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3% in non-MDR strains. This emphasises the need for easy and rapid tests for identification of PZA-R for efficient treatment of MDR-TB.”
“Objective-To determine agreement between arterial partial pressures of carbon dioxide (Paco(2)) and end-tidal partial pressures of carbon dioxide (P(ETCO2)) measured with a nasal catheter in spontaneously breathing, critically ill dogs.
Design-Validation study.
Animals-26 client-owned dogs admitted to an intensive care unit for various conditions.
Procedures-Paco(2) was measured with a commercial blood gas
analyzer, and P(ETCO2) was measured with a sidestream capnograph attached to a nasal catheter. Measurements were obtained twice (ie, with and without supplemental oxygen). Paired values were compared by means of the Pearson correlation method. Level of agreement was assessed by Ro-3306 nmr means of the Bland-Altman method.
Results-Mean difference between Paco(2) and P(ETCO2), when dogs did not receive supplemental oxygen (mean +/- SD, 3.95 +/- 4.92 mm Hg) was significantly lower than mean difference when dogs did receive supplemental oxygen (6.87 +/- 6.42 mm Hg). Mean difference in dogs with a condition affecting the respiratory system (8.55 +/- 5.43 mm Hg) was significantly higher than mean difference in dogs without respiratory tract disease (3.28 +/- 3.23 mm Hg). There was a significant linear correlation and good agreement between measured values of Paco(2) and P(ETCO2).