Self-directed strategy training is recommended for the remediation of mild memory deficits after TBI. For impairments of higher cognitive functioning after TBI, interventions that promote self-monitoring and self-regulation for deficits in executive functioning (including impaired self-awareness) and social communication skills interventions for interpersonal and pragmatic conversational problems are recommended after GW-572016 TBI. Comprehensive-holistic neuropsychologic rehabilitation is recommended to improve postacute participation and quality of life after moderate or severe TBI. A number of recommended Practice Standards reflect the lateralized nature

of BTK inhibitor clinical trial cognitive dysfunction that is characteristic of stroke. Visuospatial rehabilitation

that includes visual scanning training for left visual neglect is recommended after right hemisphere stroke. Cognitive-linguistic interventions for aphasia and gestural strategy training for apraxia are recommended after left hemisphere stroke. The Practice Standards for metacognitive strategy training for executive deficits and comprehensive-holistic neuropsychologic rehabilitation after TBI represent upgraded recommendations from our prior reviews. The Practice Options for errorless learning for memory deficits after TBI and for group treatments for cognitive and communication deficits after TBI or left hemisphere stroke represent new recommendations since our prior reviews. Together with our prior reviews, we now have evaluated a total of 370 interventions (65 class I or Ia, 54 class II, and 251 class III studies) that provide evidence for the comparative effectiveness of cognitive rehabilitation.

Among the 65 class I and Ia studies, there were 15 comparisons (which included 3-oxoacyl-(acyl-carrier-protein) reductase 550 participants) of cognitive rehabilitation with no active treatment. In every one of these comparisons, cognitive rehabilitation was shown to be of benefit. There were 17 comparisons (with 696 participants) between cognitive rehabilitation and conventional forms of rehabilitation. Cognitive rehabilitation was shown to be of greater benefit than conventional rehabilitation in 94.1% of these comparisons. Examining this evidence base, there is clear indication that cognitive rehabilitation is the best available form of treatment for people who exhibit neurocognitive impairment and functional limitations after TBI or stroke. Additional research needs to elucidate the mechanisms of change underlying the efficacy of cognitive rehabilitation and the comparative effectiveness of different interventions. Although not the primary focus of our reviews, there are some indications regarding consideration of patient characteristics in cognitive rehabilitation.