First infections, though often

severe, have been shown to

First infections, though often

severe, have been shown to induce immunity against subsequent infections. Vaccination with an oral vaccine is intended to mimic infections that result in protection without causing illness [4] and [5]. Two oral HDAC inhibitor rotavirus vaccines are currently licensed in over 100 countries for infants six weeks of age and older. Rotarix, an attenuated G1P[8] human strain (89-12), is administered as a two-dose series [6]. Rotateq, containing five bovine-human reassortant strains with G1, G2, G3, G4, and P[8] human surface antigens, is administered as a three-dose series [6]. The World Health Organization (WHO) has recommended the introduction of these vaccines in national immunization programs worldwide, after review of clinical trial data from Africa and Asia, and post licensure data from the Americas [7]. The protective efficacy of the rotavirus vaccine, likely involving mucosal (intestinal) and systemic antibody responses BMN 673 concentration as well as the cell-mediated immune system, is higher than expected from serum IgA measurements in some field trials, where seroconversion rates were lower than efficacy [8]. Although there is no recognized correlate of protection at the individual

level, serum anti-RV IgA antibodies are generally accepted as a marker of vaccine immunogenicity and a possible surrogate of protection at the level of the general community [9]. Well documented evidence shows Thymidine kinase that immunogenicity and efficacy

of most oral vaccines in developing countries is lower than in developed countries, in all age groups [10]. Recent studies also show that seroconversion and efficacy rates of rotavirus vaccines in low and middle-income countries in Asia and Africa [11], [12] and [13] are much lower than in the United States of America, Europe, high-income Asian and Latin American countries [14], [15], [16], [17] and [18]. Further, vaccine efficacy declines significantly in developing countries in the second year of assessment [19]. The present study was conducted to compare three and five doses of an oral rotavirus vaccine for immunogenicity to determine whether increasing the number of doses increases the proportion of children responding to the vaccine, similar to the phenomenon observed in developing countries with the oral polio vaccine (OPV) [20]. This phase IV randomized, parallel group comparison study was conducted in the Well Baby Clinic of Christian Medical College (CMC) in Vellore, south India between March and December 2012. The study protocol was approved by the CMC Institutional Review Board and the trial was registered with the Clinical Trials Registry of India (CTRI/2012/02/002454). Healthy term infants with a birth weight ≥2 kg aged less than seven weeks attending the Well Baby Clinic at CMC Vellore for routine immunization were invited to participate in the study.

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