Acknowledgment We would like to thank Mrs. Faranak Pormonsefi for her cooperation. Financial supports from the Hamedan University of Medical Science is gratefully acknowledged. Conflict of Interest: None declared
Background: The Endometriosis Health Profile-30 (EHP-30) is a disease-specific questionnaire to measure the health-related quality of life in patients

with endometriosis. The aim of this study was to evaluate the validity and reliability Inhibitors,research,lifescience,medical of the Persian Selleck p53 inhibitor version of Endometriosis Health Profile (EHP-30) in women with endometriosis referring to three Gynecology Clinics in Tehran, Iran. Methods: One hundred women (20 to 50 years old) with surgically confirmed endometriosis recruited from three outpatient Gynecology Clinics affiliated to the Iran University of Medical Sciences. All 100 patients were asked to complete EHP-30 questionnaire while referring to the Clinics. The findings were analyzed using descriptive statistics, internal reliability consistency, Inhibitors,research,lifescience,medical construct validity (using short form-36, which had already Inhibitors,research,lifescience,medical been validated in Iran), factor analysis (with principle component analysis method), and

item total correlation to assess the validity and reliability of the questionnaire. Results: The internal consistency reliability of the questionnaire was high (Cronbach’s α ranged between 0.80 and 0.93 for core, and 0.78 and 0.90 for modular parts). All items were loaded on their own factors except item 17 (feeling aggressive or violent) and item 18 (feeling unwell), which

were loaded on pain and social support domains, respectively. Inhibitors,research,lifescience,medical Construct validity of EHP-30, established by using SF-36, indicates good correlations in several similar scales of these two questionnaires. Conclusion: The findings of the study demonstrate that Persian version of EHP-30 is a valid and reliable measure to assess the quality of life in women with endometriosis. Key Words: Endometriosis, quality of life, Inhibitors,research,lifescience,medical validity, reliability, endometriosis health profile Introduction Endometriosis is a common gynecological condition that is associated with a variety of symptoms, most commonly chronic pelvic pain. Endometriosis affects near seven million women in the United States, and more than 70 million worldwide.1 Other reported estimates of Physiological Reviews the prevalence of endometriosis range from 1% to 52%,2,3 and the most frequently reported rate was 10%.2,4 The symptoms associated with endometriosis are major causes of morbidity and psychological complaints. Women with endometriosis have social dysfunction, feelings of frustration and isolation due to pelvic pain, infertility problems and a delay in diagnosis.5 In recent years, studies have begun to assess the effects of endometriosis on health-related quality of life (HRQL).